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Published Date: November 15, 2025
Title: Deciphering the Same Lifetimes of mRNA and the p53 Target Protein
Author: Dr. Xiaomin Shi
Abstract: The tumour suppressor protein p53 is a transcription factor. After DNA damage, p53 concentrations exhibit pulsed or sustained dynamics that results in a number of target genes expression, triggering different cell fate. For p53 target genes, the mRNA decay rate constants of PUMA, MDM2, p21, and BAX are 73 h-1，0.27 h-1, 0.265 h-1, and 0.018 h-1, respectively; the protein degradation rate constants are 0.056h-1, 0.792 h-1, 0.255 h-1, and 0.0262 h-1, respectively. What is the biological significance of the same lifetimes of mRNA and protein? For sustained p53 dynamics input, using a minimal model, I found that the same lifetimes of mRNA and protein can provide high sensitive target protein expression, drive protein expression to reach maximum at the shortest time. This result may be help for designing gene expression.
Publisher:
Global Journals
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Title: Deciphering the Same Lifetimes of mRNA and the p53 Target Protein
Author: Dr. Xiaomin Shi
Part: Vol.25 Issue 1
Abstract: The tumour suppressor protein p53 is a transcription factor. After DNA damage, p53 concentrations exhibit pulsed or sustained dynamics that results in a number of target genes expression, triggering different cell fate. For p53 target genes, the mRNA decay rate constants of PUMA, MDM2, p21, and BAX are 73 h-1，0.27 h-1, 0.265 h-1, and 0.018 h-1, respectively; the protein degradation rate constants are 0.056h-1, 0.792 h-1, 0.255 h-1, and 0.0262 h-1, respectively. What is the biological significance of the same lifetimes of mRNA and protein? For sustained p53 dynamics input, using a minimal model, I found that the same lifetimes of mRNA and protein can provide high sensitive target protein expression, drive protein expression to reach maximum at the shortest time. This result may be help for designing gene expression.
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
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Published Date: November 15, 2025
Title: Natural Ways to Improve Sleep Quality and Energy: The Role of Melatonin and Healthy Lifestyle Habits
Author: Okilakhon Nusratova, Assoc. Prof. Gulzira Ismoilova
Abstract: Melatonin is a key hormone that regulates the sleep–wake cycle and supports the body’s biological rhythm. It plays a vital role in improving sleep quality, energy production, and mental concentration. This study explores the physiological functions of melatonin, its effects on sleep, and the natural ways to enhance melatonin levels through diet. The research also demonstrates how melatonin supplementation can temporarily aid sleep improvement, followed by a transition to maintaining healthy sleep naturally.
Publisher:
Global Journals
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Title: Natural Ways to Improve Sleep Quality and Energy: The Role of Melatonin and Healthy Lifestyle Habits
Author: Okilakhon Nusratova, Assoc. Prof. Gulzira Ismoilova
Part: Vol.25 Issue 1
Abstract: Melatonin is a key hormone that regulates the sleep–wake cycle and supports the body’s biological rhythm. It plays a vital role in improving sleep quality, energy production, and mental concentration. This study explores the physiological functions of melatonin, its effects on sleep, and the natural ways to enhance melatonin levels through diet. The research also demonstrates how melatonin supplementation can temporarily aid sleep improvement, followed by a transition to maintaining healthy sleep naturally.
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Read Article
Published Date: October 15, 2025
Title: Five Decades of Hydrological, Vegetation and Biodiversity Responses to Climate Change in a Southwestern Australian Jarrah ( Eucalyptus marginata) forest (1972-2024)
Author: Frank Batini
Abstract: Water is a key driver for many ecosystem processes. The integration of various sets of data for the 2000 ha 31 Mile Brook catchment allows an holistic evaluation of the responses by this ecosystem to substantial changes in hydrology. Excellent baselines for hydrology and vegetation are available from 1972. From the late 1960’s there has been a major reduction in rainfall in the South-West of Western Australia and an even greater decline in stream flow. Modelling simulations closely matched the observed drying trends in stream flow, flow days and groundwater depth. The model was then used to estimate the impact of thinning treatments on these values. Between 2004 and 2010, the estimated evapotranspiration matched the average rainfall and soil moisture storage fell. Estimates of Leaf Area (LAI) show steady canopy growth after good rainfall years (to 1.5) and then a substantial decline, as a result of the very dry 2010 winter. Crown scorch and some tree deaths on shallow soils were observed in autumn 2011 and again in 2024. Detailed mapping of species composition in 1972 and remapping in 2012 showed only a slight xeric shift. In 2024, the tree stratum was healthy, but small changes in composition were observed, some as the result of a prescribed burn, others due to drought. Aquatic biodiversity between 1984 and 2010 reveal shifts in faunal assemblages, species richness and abundance, but only for a few species that have longer life cycles. A range of terrestrial biota show little change, as the understorey vegetation on which they depend for food and shelter is still healthy. So far, this ecosystem has shown remarkable resilience to a changing climate. Modelling suggests that thinning the tree stratum to a basal area of 14 would benefit soil moisture and increase stream flow. Thinning for ecosystem health is now approved in the Forest Management Plan (DBCA 2024). Recommendations for ongoing management and research are made.
Publisher:
Global Journals
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Title: Five Decades of Hydrological, Vegetation and Biodiversity Responses to Climate Change in a Southwestern Australian Jarrah ( Eucalyptus marginata) forest (1972-2024)
Author: Frank Batini
Part: Vol.25 Issue 3
Abstract: Water is a key driver for many ecosystem processes. The integration of various sets of data for the 2000 ha 31 Mile Brook catchment allows an holistic evaluation of the responses by this ecosystem to substantial changes in hydrology. Excellent baselines for hydrology and vegetation are available from 1972. From the late 1960’s there has been a major reduction in rainfall in the South-West of Western Australia and an even greater decline in stream flow. Modelling simulations closely matched the observed drying trends in stream flow, flow days and groundwater depth. The model was then used to estimate the impact of thinning treatments on these values. Between 2004 and 2010, the estimated evapotranspiration matched the average rainfall and soil moisture storage fell. Estimates of Leaf Area (LAI) show steady canopy growth after good rainfall years (to 1.5) and then a substantial decline, as a result of the very dry 2010 winter. Crown scorch and some tree deaths on shallow soils were observed in autumn 2011 and again in 2024. Detailed mapping of species composition in 1972 and remapping in 2012 showed only a slight xeric shift. In 2024, the tree stratum was healthy, but small changes in composition were observed, some as the result of a prescribed burn, others due to drought. Aquatic biodiversity between 1984 and 2010 reveal shifts in faunal assemblages, species richness and abundance, but only for a few species that have longer life cycles. A range of terrestrial biota show little change, as the understorey vegetation on which they depend for food and shelter is still healthy. So far, this ecosystem has shown remarkable resilience to a changing climate. Modelling suggests that thinning the tree stratum to a basal area of 14 would benefit soil moisture and increase stream flow. Thinning for ecosystem health is now approved in the Forest Management Plan (DBCA 2024). Recommendations for ongoing management and research are made.
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
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Published Date: October 15, 2025
Title: Formulation and development of herbal moisturizing scrub
Author: Srushti Sharad Dhumane, Vrushali S Ghuge, Dr. Latesh Patil, Dr. M. R. N Shaikh
Abstract: The present study focuses on the formulation and evaluation of a herbal moisturizing scrub designed specifically for individuals with dry and sensitive skin. Conventional scrubs containing synthetic or harsh exfoliants often lead to irritation, redness, and dryness, necessitating additional moisturizing products. To overcome these drawbacks, a mild exfoliating formulation combining Shata Dhauta Ghrita(SDG) and jojoba beads was developed. SDG, prepared by washing clarified cow ghee one hundred times, serves as a traditional Ayurvedic emollient with strong moisturizing and skin-soothing properties. Jojoba beads, being smooth and spherical, provide gentle exfoliation without abrasion, while Sapindusmukorossi (reetha) extract was incorporated as a natural foaming agent. The prepared formulation was evaluated for various physicochemical and performance parameters, including appearance, pH, foamability, irritability, consistency, stability, was hability, and grittiness. Results indicated that the scrub possessed a yellowish-brown color, characteristic odor, pH of 5.9 (within the skin-compatible range of 5.7–7.0), semisolid consistency, and mild grittiness due to the exfoliating agents. It was found to be stable under stress conditions, easily washable, and non-irritant. Overall, the study concludes that the herbal moisturizing scrub offers dual benefits of gentle exfoliation and intense hydration in a single step. It not only cleanses and nourishes the skin but also protects against acne, pimples, and premature aging, making it a safe and effective cosmetic option for individuals with dry, sensitive skin.
Publisher:
Global Journals
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Title: Formulation and development of herbal moisturizing scrub
Author: Srushti Sharad Dhumane, Vrushali S Ghuge, Dr. Latesh Patil, Dr. M. R. N Shaikh
Part: Vol.25 Issue 1
Abstract: The present study focuses on the formulation and evaluation of a herbal moisturizing scrub designed specifically for individuals with dry and sensitive skin. Conventional scrubs containing synthetic or harsh exfoliants often lead to irritation, redness, and dryness, necessitating additional moisturizing products. To overcome these drawbacks, a mild exfoliating formulation combining Shata Dhauta Ghrita(SDG) and jojoba beads was developed. SDG, prepared by washing clarified cow ghee one hundred times, serves as a traditional Ayurvedic emollient with strong moisturizing and skin-soothing properties. Jojoba beads, being smooth and spherical, provide gentle exfoliation without abrasion, while Sapindusmukorossi (reetha) extract was incorporated as a natural foaming agent. The prepared formulation was evaluated for various physicochemical and performance parameters, including appearance, pH, foamability, irritability, consistency, stability, was hability, and grittiness. Results indicated that the scrub possessed a yellowish-brown color, characteristic odor, pH of 5.9 (within the skin-compatible range of 5.7–7.0), semisolid consistency, and mild grittiness due to the exfoliating agents. It was found to be stable under stress conditions, easily washable, and non-irritant. Overall, the study concludes that the herbal moisturizing scrub offers dual benefits of gentle exfoliation and intense hydration in a single step. It not only cleanses and nourishes the skin but also protects against acne, pimples, and premature aging, making it a safe and effective cosmetic option for individuals with dry, sensitive skin.
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
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Published Date: October 15, 2025
Title: Quantum Superposition and the Emergence of Negative Energy in Gravitational Fields
Author: Gang Lee
Abstract: In this paper, we calculated the quantum superposition between states of the gravitational fields by Feynman path integration and concluded that in general, the quantum effects can be interpreted as the negative energy in gravitational field, it will lead to gravitational mass defect. Negative energy is related to Einstein's cosmological constant, and therefore also to dark energy.
Publisher:
Global Journals
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Title: Quantum Superposition and the Emergence of Negative Energy in Gravitational Fields
Author: Gang Lee
Part: Vol.25 Issue 5
Abstract: In this paper, we calculated the quantum superposition between states of the gravitational fields by Feynman path integration and concluded that in general, the quantum effects can be interpreted as the negative energy in gravitational field, it will lead to gravitational mass defect. Negative energy is related to Einstein's cosmological constant, and therefore also to dark energy.
ISSN: 0975-5896 ;
E-ISSN: 2249-4626 ;
DOI: 10.17406/GJSFR
Read Article
